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WILHELM LAB

Biomedical Nano-Engineering Laboratory

The Wilhelm Lab is affiliated with the Stephenson School of Biomedical Engineering (SBME) at the University of Oklahoma (OU).

Our lab space is in Gallogly Hall at the OU Norman Campus.

Our research interests include the engineering and design of nanomaterials for use in biomedical applications and clinical translation.

OU stephenson-biomedical-engineering


WILHELM LAB NEWS

ROOT4NANO Outreach at CURE Jr. – Summer 2026

July 2026 – The Wilhelm Lab’s ROOT4NANO program participated in the CURE Jr. events at the University of Oklahoma Health Center (OUHC) as part of an outreach opportunity with high school students. Thank you for the invitation!

Ph.D. Defense – Yuxin He

July 2026 – Yuxin He defended her Ph.D. thesis, “Synthesis, characterization, and biomedical applications of polysaccharide-modified mRNA-lipid nanoparticles”. Congratulations, Dr. He! Thank you to the Ph.D. committee members, Drs. Wei Chen, Qinggong Tang, and Jingyao Dai.

Publication in Analytical Chemistry

June 2026 – Mobina and the team published an original research article in the journal Analytical Chemistry. Congratulations!

Mobina Mohammadnejad, Majood Haddad, Alex N. Frickenstein, Arianna Dambold, Vinit Sheth, Jezan Alexandre, Nathan Means, Kavita Belligund, Hunter Moss, James Bowman, Jeesoo Park, Yuxin He, Stefan Wilhelm
“Label-free and high-throughput quantification of nanoparticle-cell interactions at the single-cell level with flow cytometry”
Analytical Chemistry, 2026, 98, 24, 17718–17731.
DOI: 10.1021/acs.analchem.5c08235  |  PDF (12.6 MB)

Publication in Journal of Cancer Education

May 2026 – We published a collaborative paper in the Journal of Cancer Education. Congratulations!

Cara Monroe, Amy Lyons-Ketchum, Horvey Palacios, Justin Lund, John R. Walkup, Kent Smith, Stefan Wilhelm, Ramesh Rajagopal
“YES Oklahoma: building pathways into cancer research and public health for indigenous high school students”
Journal of Cancer Education, 2026, published online.
DOI: 10.1007/s13187-026-02905-1  |  PDF (0.7 MB)

Arianna Dambold received Astronaut Scholarship Award

May 2026 – Wilhelm Lab undergraduate researcher Arianna Dambold received the prestigious 2026 Astronaut Scholarship Award.

Publication in ACS Applied Materials & Interfaces

May 2026 – Yuxin and the team published an original research article in the journal ACS Applied Materials & Interfaces. Congratulations!

Yuxin He, Lin Wang, Rameswari Velayutham, Trisha I. Valerio, Samantha D. Ricketts, Yuanhong Sun, Anand C. Annan, James Bowman, Thao Tran1, Mobina Mohammadnejad, Kaili Liu, Wei R. Chen, Dixy E. Green, Kar-Ming Fung, Paul L. DeAngelis, Stefan Wilhelm
“Lipid nanoparticle surface engineering with heparosan polysaccharides for safe and effective mRNA delivery in vitro and in vivo”
ACS Applied Materials & Interfaces, 2026, 18, 20, 28536–28555.
DOI: 10.1021/acsami.6c05213  |  PDF (13.8 MB)

ROOT4NANO Summer Research Camp 2026

May 2026 – Six high school students from rural southwest Oklahoma participated in a week-long summer research camp in the Wilhelm Lab.

Thank you to everyone for your tremendous support!

Trainee Awards – Spring 2026

April 2026 – Congratulations to the Wilhelm Lab team on receiving several trainee awards!

  • Ana Clara Morais: Digital Imaging and Vision Applications in Science (DIVAS) Alliance Scholar Program Award
  • Yuxin He: Stephenson Graduate Assistantship (SGA) Award
  • Arianna Dambold: Outstanding Sophomore Award
  • Henley Calhoun: Outstanding Junior Award
  • James Bowman: Outstanding MS Graduate Student Award
  • Sujay Gurav: SBME Translation Stimulation Award
  • Mobina Mohammadnejad: Best Micrograph Award, Oklahoma Microscopy Society
  • Henley Calhoun: Best Poster Presentation Award, Oklahoma Microscopy Society
  • Ana Clara Morais: NSF ART InTRO Award

ROOT4NANO Outreach Day – March 2026

March 2026 – We hosted 35 students from the Caddo-Kiowa Technology Center at OU-Norman to learn about biomedical engineering. Thanks to the Wilhelm Lab, the Gallogly College of Engineering (GCoE), and the Stephenson School of Biomedical Engineering (SBME) teams for the support!

Henley Calhoun received END2CANCER 2025 Poster Award

December 2025 – Wilhelm Lab undergraduate researcher Henley Calhoun received the END2CANCER 2025 poster award. Congratulations!

 

Kids Night with Microscopes – November 2025

November 2025 – The Wilhelm Lab team participated in the Oklahoma Microscopy Society “Kids Night with Microscopes” event. Through engaging hands-on demonstrations, we reached nearly 100 K–12 students and introduced them to the exciting world of bionanotechnology.

ROOT4NANO Classroom Visit – Fall 2025

November 2025 – The Wilhelm Lab team visited the student classrooms at the Caddo-Kiowa Technology Center. The students learned about nanoparticle synthesis, characterization, and clinical applications of nanomedicines.

Thank you for the great partnership!

ROOT4NANO Summer Research Camp 2025

May 2025 – Seven high school students from rural southwest Oklahoma participated in a week-long summer research camp in the Wilhelm Lab.

Thank you to everyone for your tremendous support!

Publication in ACS Nano

May 2025 – New collaborative work published in ACS Nano with various colleagues, including from the MD Anderson Cancer Center!

Y. Wang, H. Song, Y. Teng, G. Huang, J. Qian, H. Wang, S. Dong, J. H. Ha, Y. Ma, M. Chang, S. D. Jeong, W. Deng, B. R. Schrank, A. Grippin, A. Wu, J. L. Edwards, Y. Zhang, Y. Lin, W. Poon, S. Wilhelm, Y. Bi, L. Teng, Z. Wang, B. Y. S. Kim, W. Jiang, “A generative artificial intelligence copilot for biomedical nanoengineering”
ACS Nano, 2025, published online.
DOI: 10.1021/acsnano.5c03454 | PDF (7.2 MB)

NSF GRFP Award

April 2025 – Wilhelm Lab undergraduate student Logan Longacre received the NSF GRFP award! Outstanding accomplishment, Logan!

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